在老化和最早的阿尔茨海默氏症病理阶段,Locus coeruleus tau验证和告知高分辨率MRI
Alexander T Hary1, Smriti Chadha1, Nathaniel Mercaldo1,2
1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth St, Suite 2301, Charlestown, MA, 02129, USA.
Acta neuropathologica communications
|February 28, 2025
概括
在临床前的阿尔茨海默氏症中,coeruleus位 (LC) 显示了早期tau病理和缩. 这项研究使用MRI和组织学来绘制积在LC和背侧核中的图积累.
科学领域:
- 神经科学是一个神经科学.
- 神经病理学神经病理学
- 医疗成像医学成像
背景情况:
- 脑位 (LC) 涉及早期tau病理的发展,先于大脑皮层的参与.
- 了解LC中陶积累的初始阶段对于早期发现阿尔茨海默病 (AD) 至关重要.
研究的目的:
- 在阿尔茨海默氏症最早的布拉克和布拉克 (BB) 阶段,研究核 (LC) 和背面核 (DRc) 中的结构变化和病理.
- 为了将高分辨率的死后MRI数据与验证的tau组织病理学相关联.
主要方法:
- 使用高分辨率的ex vivoMRI获得LC的定量3D体积.
- 在对照和最早的BB阶段 (BBI-BBII) 的死后脑样本 (n=11) 上进行了验证的tau组织病理学.
- 使用空间矩阵绘制区域LC和DRctau严重程度的地图,并与MRI衍生结构数据相关联.
主要成果:
- 在BB 0和BB II之间的LC中观察到显著的亚缩 (30.0%),特别是在面LC中 (体积小49.2%).
- 在BB I和BB II之间表现出显著的LC tau积累 (37.6%的增加),中部LC的严重程度达到峰值.
- 揭示了DRc中tau严重性显著的 rostrocaudal梯度 (58.2%的下降),表明选择性的区域脆弱性.
结论:
- 在LC和DRc中,tau病理和结构性缩发生在临床前AD阶段 (BB I-II).
- 结果突出显示,LC和DRc是早期AD相关病理的关键区域.
- 这项研究提供了有价值的空间重建,用于未来的LC体内成像研究.
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