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Updated: May 24, 2025

Production of Large Numbers of Size-controlled Tumor Spheroids Using Microwell Plates

Production of Large Numbers of Size-controlled Tumor Spheroids Using Microwell Plates

Published on: November 18, 2013

高通量可编程瘤球体生成使用磁铁-阿基米德斯效应.

Xiangxiang Zhang¹, Chao Li¹, Shubin Li¹

¹State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, 92 West Da-Zhi Street, Harbin 150001, China.

ACS applied materials & interfaces

|March 1, 2025

概括

这项研究提出了一种具有成本效益的,非侵入性的方法,使用磁铁-阿基米德效应来创建用于药物发现和组织工程的3D瘤球形. 这些球形模仿真实组织,使得先进的癌症研究成为可能.

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科学领域:

生物技术是生物技术.
生物医学工程生物医学工程
癌症研究癌症研究

背景情况:

三维 (3D) 瘤球体模仿体内瘤微环境,对于药物发现和组织工程至关重要.
现有的球体生成方法可能是耗时的,昂贵的或侵入性的.

研究的目的:

开发一种简单,具有成本效益和非侵入性的高吞吐量方法,用于生产3D瘤球体.
为了证明这些球体在抗癌药物查,瘤注射和研究细胞-组织相互作用中的实用性.

主要方法:

利用磁铁-阿基米德斯效应进行球形形成.
采用不同的模板和细胞排序来实现多功能球形形态和空间编码.
通过免疫光检测验证了球形状与小鼠同移植瘤的相似性.

主要成果:

成功生产了具有高通量能力的多功能3D瘤球体.
在使用这些球状体治疗质瘤时,Temozolomide (TMZ) 与5-FU相比已经证明有效.
从C6球状体的小鼠中成功显示瘤生长,并通过从人工细胞聚合物中通过反应性氧物种 (ROS) 扩散在瘤细胞中诱导亡.

结论:

关键词:

药物查对药物进行查.混合结构混合结构混合结构磁铁-阿基米德斯效应的影响组织移植组织移植瘤球形状的球形状

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Generation of 3D Tumor Spheroids for Drug Evaluation Studies

Generation of 3D Tumor Spheroids for Drug Evaluation Studies

Published on: February 24, 2023

相关实验视频

Last Updated: May 24, 2025

Production of Large Numbers of Size-controlled Tumor Spheroids Using Microwell Plates

Production of Large Numbers of Size-controlled Tumor Spheroids Using Microwell Plates

Published on: November 18, 2013

Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening

Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening

Published on: September 5, 2018

Generation of 3D Tumor Spheroids for Drug Evaluation Studies

Generation of 3D Tumor Spheroids for Drug Evaluation Studies

Published on: February 24, 2023

磁铁-阿基米德效应为生成3D瘤球形提供了可扩展和高效的方法.

这些球体是抗癌药物查,体内瘤建模和理解细胞间信号传递的宝贵工具.

该方法具有复杂的组织工程和先进的癌症研究应用的巨大潜力.