基于氧化高氨糖粉的益生菌输送系统的构造,特征和特性
Bin Zhang1, Chenxin Wang1, Shuang Liang1
1School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034 PR China; National & Local Joint Engineering Laboratory for Marine Bioactive Polysaccharide Development and Application, Dalian Polytechnic University, Dalian 116034 PR China.
Food research international (Ottawa, Ont.)
|March 1, 2025
概括
这项研究开发了一种新型的甲基酸盐/氧化高粉复合载体,以保护Lacticaseibacillus rhamnosus GG益生菌. 载体增强了胃肠道中的益生菌存活率,并确保有针对性的肠道释放以改善输送.
科学领域:
- 生物材料科学 生物材料科学
- 食品科学 食品科学 食品科学
- 微生物学 微生物学
背景情况:
- 益生菌需要有效的输送系统才能在胃肠道中生存.
- 氧化粉为开发功能性食品成分提供了潜力.
- 酸是微封装的常见材料之一.
研究的目的:
- 为了制备和表征基酸盐/氧化高粉 (SA/OHAS) 复合物.
- 评估SA/OHAS复合物作为Lacticaseibacillus rhamnosus GG (LGG) 益生菌的载体.
- 在模拟的胃肠道条件下,评估SA/OHAS载体内LGG的生存和释放.
主要方法:
- 用不同的氧化度准备OHAS.
- 风病学分析来选择最佳的SA/OHAS复合物.
- 在模拟的胃和肠液中进行封装效率和益生菌活力测试.
- 在小鼠体内肠道过境可视化.
主要成果:
- 确定了一种具有出色粘性弹性和稳定的SA/OHAS复合物.
- 在胃消化后,高封装效率 (46.21%) 和显著的益生菌存活率 (5.87 × 10^6 CFU/mL).
- 益生菌在肠液中的快速释放 (85.67%在2小时内).
- 在体内研究证实了老鼠肠道中长时间的益生菌保留.
结论:
- 该SA/OHAS复合物有效地保护LGG益生菌在胃肠道过境期间.
- 这种载体系统促进了有针对性的肠道输送,并增强了益生菌的活力.
- SA/OHAS提出了一个有前途的策略,用于口服食品应用中的益生菌封装.
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