Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Telomeres and Telomerase02:41

Telomeres and Telomerase

22.9K
In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
22.9K
Replication in Eukaryotes01:29

Replication in Eukaryotes

12.9K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
12.9K
Replicative Cell Senescence02:15

Replicative Cell Senescence

3.6K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
3.6K
Chromosome Replication02:31

Chromosome Replication

8.6K
Before a cell can divide, it must accurately replicate all of its chromosomes, including the DNA and its associated histone and non-histone proteins.  This process begins at numerous origins of replication during the S phase of the cell cycle in each of a cell’s chromosomes simultaneously. Certain nucleotides can act as origins of replication, but these sequences are not well defined - especially in complex, multi-cellular, eukaryotic species. The length of DNA that spans an origin...
8.6K
Histone Variants at the Centromere02:30

Histone Variants at the Centromere

4.3K
Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
4.3K
Chromosome Structure02:40

Chromosome Structure

22.5K
A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
22.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Mothers Matter Most: Maternal, but Not Paternal, Age and Inbreeding Affect Nestling Telomere Length in a Wild Passerine.

Molecular ecology·2026
Same author

Telomere dynamics, not absolute telomere length, predicts lifespan in adult zebra finches.

Journal of evolutionary biology·2026
Same author

A mechanistic understanding of collective escape in starling flocks.

Communications biology·2026
Same author

Sex-Chromosome-Dependent Ageing in Female Heterogametic Methylomes.

Molecular ecology·2025
Same author

No Evidence That Life History Strategies Shape Within-Body Mosaics of Ageing.

Molecular ecology·2025
Same author

REMOVED: Long Donor Leukocyte Telomeres Increase the Risk of Severe COVID-19 in Recipients of Allogeneic Hematopoietic Cell Transplant.

Transplantation and cellular therapy·2025
Same journal

Age-Associated Senescence of Decidual Macrophages: A Key Mediator of Adverse Pregnancy Outcomes in Advanced Maternal Age.

Aging cell·2026
Same journal

Correction to "Telomerase Knockout in Myeloid Cells Predisposes Mice to Foam Cell Formation, Dyslipidemia, Lung Fibrosis, and Cardiac Dysfunction".

Aging cell·2026
Same journal

Bidirectional Relationship and Shared Mechanisms Between Sarcopenia and Osteoporosis: An Observational Study Integrating Genomic, Proteomic, and Metabolomic Data.

Aging cell·2026
Same journal

Clonal Analyses Reveal the Impact of Hematopoietic Stem and Progenitor Cell Aging on T Cell Development.

Aging cell·2026
Same journal

A Gut-Centric View of Ageing: A Pilot Analysis Mapping Age-Associated Immune and Molecular Alterations in Colonic Mucosa Using Spatial Proteomics.

Aging cell·2026
Same journal

Correction to "Environmental Enrofloxacin Exposure as a Modifiable Driver of Mitochondria-Mediated Intestinal Aging and Barrier Dysfunction".

Aging cell·2026
查看所有相关文章

相关实验视频

Updated: May 24, 2025

Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells
09:13

Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells

Published on: January 17, 2019

7.3K

太空中的端粒

Abraham Aviv1, Simon Verhulst2

  • 1Center of Human Development and Aging, New Jersey Medical School, Rutgers State University of New Jersey, Newark, New Jersey, USA.

Aging cell
|March 1, 2025
PubMed
概括
此摘要是机器生成的。

太空飞行似乎延长了免疫细胞的端粒. 然而,这可能是由于免疫细胞类型的变化,而不是单个细胞内较长的端粒. 了解这些变化对于宇航员健康至关重要.

关键词:
宇航员 宇航员 太空人淋巴细胞 淋巴细胞中性粒细胞中性粒细胞.空间空间空间空间空间的空间.端粒是什么意思 端粒是什么意思

更多相关视频

Author Spotlight: Advanced Single-Molecule Techniques for Investigating Telomeric Protein-DNA Interactions
11:21

Author Spotlight: Advanced Single-Molecule Techniques for Investigating Telomeric Protein-DNA Interactions

Published on: August 30, 2024

616
Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

46.4K

相关实验视频

Last Updated: May 24, 2025

Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells
09:13

Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells

Published on: January 17, 2019

7.3K
Author Spotlight: Advanced Single-Molecule Techniques for Investigating Telomeric Protein-DNA Interactions
11:21

Author Spotlight: Advanced Single-Molecule Techniques for Investigating Telomeric Protein-DNA Interactions

Published on: August 30, 2024

616
Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

46.4K

科学领域:

  • 太空飞行免疫学
  • 细胞衰老 细胞衰老
  • 生物医学研究的研究.

背景情况:

  • 众所周知,太空飞行会引起各种生理变化.
  • 白细胞端粒长度 (LTL) 是衰老和疾病的生物标志物.
  • 以前的研究表明,宇航员的LTL延长,这是一个令人费解的观察.

研究的目的:

  • 调查报告的太空飞行引起的LTL延长背后的潜在机制.
  • 为了确定观察到的LTL变化是否反映了真正的端粒延长或白细胞子集分布的变化.
  • 为了澄清影响太空环境中LTL的因素.

主要方法:

  • 分析白细胞子集组成.
  • 在特定白细胞群体内测量端粒长度.
  • 飞行前和飞行后样本的比较.

主要成果:

  • 在太空飞行中观察到的LTL增加可能归因于不同白细胞子集相对比例的变化.
  • 没有证据表明单个白细胞类型内的实际端粒延长.
  • 固有较长端粒的特定子集在太空飞行期间可能会增加循环.

结论:

  • 在太空飞行中白细胞端粒的明显延长是一种组成效应,而不是细胞衰老逆转.
  • 需要进一步的研究来了解这些子集转移对免疫和健康的影响.
  • 准确评估LTL需要考虑白细胞子集动态在太空飞行研究.