PLGA和癌症:基于专利的综合审查,对当前的技术状况进行综合审查
Venessa Nath1, Mohini Singh1, Bani Kumar Jana1
1Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, India.
Pharmaceutical patent analyst
|March 1, 2025
概括
聚 (乳糖-co-甘油酸) (PLGA) 纳米颗粒被FDA批准用于药物输送. 本综述汇总了2008-2024年关于PLGA纳米粒子癌症疗法的全球专利,为未来的研究提供了见解.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 在瘤学瘤学.
背景情况:
- 聚 (乳糖合糖酸) (PLGA) 是一种生物相容,可生物降解的聚合物,由美国FDA批准用于药物输送.
- PLGA纳米粒子提供受控和持续释放,低毒性和组织兼容性.
- 对于PLGA纳米粒子在癌症治疗中的应用存在广泛的研究和全球专利.
研究的目的:
- 编译和审查全球专利文献,以纳米技术为基础的PLGA纳米粒子用于癌症治疗.
- 分析PLGA纳米粒子制造,表征,表面修饰,药物封装和向策略.
- 在癌症治疗中提供PLGA纳米粒子研究领域的全面概述.
主要方法:
- 从2008年到2024年对专利数据库 (Espacenet,专利范围) 进行系统审查.
- 包括与PLGA纳米粒子和各种癌症类型相关的专利.
- 专利内容的分析,包括配方,交付和治疗应用.
主要成果:
- 该审查涵盖了十年的PLGA纳米粒子专利文学,用于癌症治疗.
- 确定的主要领域包括制造,药物封装和瘤向策略.
- 这是同类的第一个汇编,突出了基于PLGA的癌症纳米技术的全球创新.
结论:
- 在纳米技术驱动的癌症治疗中,PLGA纳米颗粒代表着一个重要的创新领域.
- 专利景观揭示了用于瘤学的PLGA纳米粒子开发的各种方法.
- 本综述是PLGA纳米粒子癌症配方研究人员和开发人员的基础资源.
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