心血管疾病脂质和脂蛋白生物标志物标准化标准化
Alicia N Lyle1, Uliana Danilenko1, Otoe Sugahara1
1Division of Laboratory Sciences, Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA.
Critical reviews in clinical laboratory sciences
|March 1, 2025
概括
标准化心血管疾病 (CVD) 生物标志物可确保准确的风险评估. 新的阿波利波蛋白测量提供了更好的心血管疾病风险检测,突出了持续标准化工作的必要性,以改善患者护理.
科学领域:
- 临床化学 临床化学
- 生物标志物标准化的标准化
- 心血管疾病风险评估心血管疾病风险评估
背景情况:
- 心血管疾病 (CVD) 仍然是全球主要的死亡原因.
- 对心脏病风险评估和治疗的临床实践指南已经发展.
- 精确测量脂质和脂蛋白生物标志物对于有效的心血管疾病管理至关重要.
研究的目的:
- 审查心血管疾病生物标志物测量的变化,与不断变化的临床指南保持一致.
- 讨论传统和新型心血管疾病生物标志物的可比性和标准化状态.
- 突出测试标准化对可靠的心血管疾病风险评估的重要性.
主要方法:
- 对心血管疾病脂质和脂蛋白生物标志物测量变化的审查.
- 分析标准化因素的讨论:校准,分析灵敏度,选择性和稳定性.
- 对包括LDL-C,HDL-C,Lp(a) 和阿波利波蛋白 (apo) A-I和B.在内的关键生物标志物的当前标准化状态的分析.
主要成果:
- 标准化确保可比和可靠的生物标志物测量,这对于临床实践至关重要.
- 脂蛋白 (apoB和Lp(a)) 可能比传统的脂质提供更准确的心血管疾病风险评估.
- 疾病控制和预防中心 (CDC) 的心血管疾病生物标志物标准化计划 (BSP) 维持了血液脂质的标准化.
结论:
- 通过标准化确保心血管疾病生物标志物测量的可比性和可靠性,对于指导方针的实施和患者护理至关重要.
- 需要为apoA-I和B提供新的参考系统,强调合作网络对标准化可持续性的重要性.
- 美国疾病预防控制中心的CVD BSP将继续加强传统和新兴CVD生物标志物的标准化.
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
41
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
41
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
116
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
116
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
79
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
79
01:31Lipid-derived Compounds in the Human Body
4.3K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.3K
01:29Cholesterol: Significance and Regulation
496
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
496
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
506
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
506