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解读城市化环境,肠道微生物组和心脏代谢疾病的三方相互作用
Avaneesh Shukla1, Chanchal Sharma1, Md Zubbair Malik2
1Department of Environmental Studies, University of Delhi, New Delhi, India.
Journal of environmental management
|March 1, 2025
概括
城市化破坏了肠道微生物群,增加了心脏代谢疾病 (CMD) 的风险. 针对肠道细菌的策略,如饮食和益生菌,可以预防和治疗CMD.
科学领域:
- 微生物组研究的研究.
- 心脏代谢疾病 (CMD) 是一种心脏代谢疾病.
- 城市化影响城市化影响.
背景情况:
- 快速的城市化推动了人口迁移,特别是在亚洲和非洲.
- 城市生活方式 (出生模式,饮食,污染) 改变肠道微生物组的组成和功能.
- 由改变的细菌比率和减少的有益细菌标志着肠道失生症,与增加的CMD有关.
研究的目的:
- 审查城市化对肠道微生物组相关心脏代谢疾病的影响.
- 探索将肠道失调与CMD病原体联系起来的机制.
- 讨论CMD预防和治疗的微生物向干预措施.
主要方法:
- 关于城市化,肠道微生物组和CMD的综合文献综述.
- 对详细说明肠道微生物组成和功能变化的研究进行分析.
- 检查受 дисбиоз影响的分子和生理路径.
主要成果:
- 城市化引起的肠道失生症改变了Firmicutes/Bacteroides比率,并减少了短链脂肪酸生产者.
- 失生症破坏宿主肠道平衡,影响免疫反应,肠道屏障完整性和新陈代谢.
- 有助于炎症的肠道环境和代谢性内毒性与CMD风险增加有关.
结论:
- 城市化显著影响肠道微生物群,导致心脏代谢疾病.
- 通过饮食,生活方式,益生菌和益生菌向肠道微生物群提供了潜在的治疗策略.
- 将基于微生物组的方法集成到临床实践中可以提高CMD管理.
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