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验证多肌痛类风湿性活动得分:一个前性队列研究

Lien Moreel¹, Michaël Doumen², Albrecht Betrains¹

¹Department of General Internal Medicine, UZ Leuven, Leuven, Belgium; Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.

Seminars in arthritis and rheumatism

|March 1, 2025

概括

多肌痛类风湿性活动评分 (PMR-AS) 有效地识别了活跃的疾病. 在比利时的一项队列研究中,一种结合功能和刚性的替代PMR-AS显示出略有改善的性能.

科学领域:

类风湿病学类风湿病学
临床评估临床评估
疾病活动评分疾病活动评分

背景情况:

多发性肌痛风湿症 (PMR) 需要可靠的工具来评估疾病活动.
当前活动得分在特定的临床场景中可能有局限性.

研究的目的:

为了验证现有的多肌痛类风湿性活动评分 (PMR-AS).
评估一种新开发的替代PMR-AS,其中包括视觉模拟尺度 (VAS) 功能和详细的刚度评估.

主要方法:

包括133名PMR患者 (419次访问) 在卢旺大学医院的前性队列研究.
使用接收器运行特征曲线 (AUC) 下面面积的区分能力的评估.
使用德隆的测试和GEE-逻辑模型进行PMR-AS,替代PMR-AS和其他相关得分的比较.

主要成果:

原来的PMR-AS显示出良好的区分能力 (AUC 0.938).
替代的PMR-AS实现了更高的AUC (0.948) 与最佳切断值在13.5,显示出优越的性能.
在检测活跃疾病方面,PMR-AS和其他测试变异的变化表现明显比原始PMR-AS差.

结论:

PMR-AS是检测活跃PMR疾病的有效工具.
替代的PMR-AS提供了略有改善的歧视能力.
不依赖C-反应蛋白 (CRP) 的活动得分在患者接受影响CRP的疗法时是有价值的.

关键词:

多发性肌痛风湿症 PMR PMR活动得分

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