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先进的安福特素-B凝配方:一种有效的方法来对抗皮肤莱什曼病

Carla Veronica Rodarte de Moura¹, Diego Botelho Campelo Leite², Edvani Curti Muniz¹

¹Department of Chemistry, Federal University of Piauí, Teresina, PI, Brazil.

Biomaterials advances

|March 1, 2025

概括

使用安全的共聚合物的新型安福特素-B (AmB) 凝有效地通过减少70%的寄生虫来治疗皮肤莱什曼病. 这些充满AmB的凝可以最大限度地降低药物毒性,并改善莱什曼病治疗的治疗效果.

科学领域:

聚合物化学聚合物化学
药物输送系统是药物输送系统.
传染病研究传染病研究.

背景情况:

传统的安福特里辛-B (AmB) 面临着水溶性差和胃肠道刺激等局限性.
皮肤莱什曼病需要有效的药物输送系统来克服治疗挑战.

研究的目的:

开发和描述用于皮肤雷什曼病治疗的新型AMB载荷共聚合物凝 (TMP-HPG-PCL和GLY-HPG-PCL).
为了评估这些AMB载荷凝的安全性,药物释放概况和治疗疗效.

主要方法:

凝是使用与AmB结合的多糖醇和e-caprolactone共聚物合成的.
鉴定包括FTIR,NMR,TG和DSC技术.
在实验室中进行了药物释放,血液溶解和细胞毒性研究,随后在Leishmania主要感染的小鼠中进行了体内疗效测试.

主要成果:

在共聚合物中,AmB仍然以其毒性较低的单体形式存在.
实现了高AMB负载 (31%) 和封装效率 (93%).
这些凝显示出受控的AmB释放,在小鼠中显著降低了寄生虫负载 (70%),并且对HaCat和MCF-7细胞系没有毒性.

结论:

开发的TMP-HPG-PCL和GLY-HPG-PCL共聚物是AmB.的安全有效的药物载体.
这些充满AMB的凝显示出对抗皮肤莱什曼病的巨大潜力,并提高了安全性和有效性.

关键词:

阿姆福特里辛-B-B 的使用.聚合物的共聚物.毒品运输商毒品运输商莱什曼病是一种莱什曼病.纳米颗粒纳米颗粒波洛克萨默-407的使用方法

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