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母婴饮食对急性白血病的发展起着作用:一个扩展的系统审查和元分析

M Karen Flores-García¹, Gisela Flores-Collado¹, Ángel Mérida-Ortega¹

¹Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública (INSP), Cuernavaca, Morelos, Mexico.

Clinical nutrition ESPEN

|March 1, 2025

概括

母婴饮食影响急性白血病 (AL) 风险. 加工肉类和咖啡的消费与增加AL风险有关,而母体摄入的蔬菜和水果显示有保护作用.

科学领域:

流行病学流行病学
儿科瘤学儿科瘤学
营养科学营养科学

背景情况:

急性白血病 (AL),包括急性淋巴性白血病 (ALL) 和急性髓性白血病 (AML),是严重的健康问题,特别是在儿童中.
新出现的证据表明,饮食和AL发展之间存在潜在的联系.
本综述综合了有关婴儿和母亲饮食模式与AL风险有关的现有研究.

研究的目的:

系统地审查和元分析观察性研究,调查AL与儿童及其母亲的饮食因素之间的关联.
扩大之前的审查,包括对多个数据库的全面搜索.

主要方法:

在PubMed/Medline,Lilacs,Scopus和Web of Science进行了广泛的电子搜索,截至2022年4月.
包括的研究是观察性,检查AL (ALL/AML) 与儿童和/或母亲的饮食相关.
分析采用固定效应模型,使用Q统计和I2.2评估异质性. 偏差风险使用纽卡斯尔-太华尺度进行评估.

主要成果:

分析了15项研究 (1组,14例对照),重点关注母亲饮食 (9项研究),儿童饮食 (4项研究) 或两者 (2项研究).
儿童食用加工肉类显示出与AL (OR=1.72) 的积极关联,而蔬菜摄入量则相反相关 (OR=0.61).
母亲的水果消费与ALL风险降低有关 (OR=0.71),而母亲的咖啡摄入与AL (OR=1.20) 和ALL (OR=1.31) 风险增加有关.

结论:

这些发现支持母亲和早期婴儿饮食在急性白血病病因学中起着重要作用.
特定的饮食成分,如加工肉类,蔬菜,水果和咖啡,可能会影响AL风险.
对饮食干预措施的进一步研究可能对AL预防策略有益.

关键词:

儿童饮食儿童饮食儿童白血病在儿童白血病.孕产妇的饮食孕产妇的饮食审查审查审查审查

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