胎儿从婴儿期到青春期暴露于酸盐和体重指数. 这一研究是"R世代"研究
Chalana M Sol1, Geneviève Delgado1, Kurunthachalam Kannan2
1The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Environmental research
|March 1, 2025
概括
产前暴露于特定的酸盐与早期的儿童体质指数 (BMI) 较低有关,但在儿童时期晚些时候的BMI较高. 这表明,酸盐可能会影响长期肥胖的发展.
科学领域:
- 环境健康 环境健康
- 儿科内分泌学 儿科内分泌学
- 毒理学 毒理学 毒理学
背景情况:
- 产前暴露于内分泌干扰化学物质,如酸盐,是一个日益严重的公共卫生问题.
- 儿童肥胖是一种复杂的疾病,具有潜在的发育起源.
- 以前的研究经常在单个时间点评估身体质量指数 (BMI),可能错过了关键的发育轨迹.
研究的目的:
- 调查产前甲酸盐暴露与从婴儿期到青春期的纵向体重指数 (BMI) 发展之间的关联.
- 为了确定特定的甲酸代谢物或怀孕期间暴露时间是否会影响BMI轨迹.
主要方法:
- 一项基于人口的队列研究包括1379对母婴.
- 在第一,第二和第三季度收集母亲的尿液样本,以测量甲酸盐度.
- 纵向BMI标准偏差分数 (SDS) 从6个月到13岁计算.
- 使用线性混合效应模型分析了产前甲酸盐暴露与重复测量BMI之间的关联.
主要成果:
- 较高的第一季度高分子量甲酸盐和二-2-乙基甲酸盐 (DEHP) 暴露与6个月后更低的BMI有关.
- 相反,较高的第一季度暴露于酸和低分子重量的酸盐与13年后的BMI增加有关.
- 没有发现第二或第三季度甲酸盐暴露与BMI结局的显著关联.
结论:
- 产前甲酸盐暴露可能对整个儿童时期的BMI发展产生差异性影响.
- 怀孕早期对某些酸盐的暴露与早期生活中的BMI较低,但儿童后期的BMI较高有关.
- 这些发现凸显了酸盐在儿童肥胖发展轨迹中的潜在作用.
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