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怀孕期间的PBDE度和青少年的执行功能与自我和护理人员报告:HOME研究

Kim M Cecil¹, Yingying Xu², Aimin Chen³

¹Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Environmental research

|March 1, 2025

概括

怀孕期间接触阻燃剂,聚二乙烯 (PBDE),与青少年的执行功能缺陷有关. 较高的PBDE水平与认知和情绪调节方面的挑战增加有关,特别是在男性中.

科学领域:

环境健康环境健康
神经发育毒理学神经发育毒理学
生殖流行病学生殖流行病学

背景情况:

聚二乙烯 (PBDE) 是一种持久性有机污染物,以前被用作阻燃剂.
产前暴露于PBDE与对人类行为,情绪和认知的不良影响有关.

研究的目的:

调查孕期母亲血清PBDE度与青春期早期执行功能之间的关联.
检查妊娠期PBDE暴露对执行功能影响的潜在性别差异.

主要方法:

一项前性队列研究测量了孕妇的血清PBDE度.
执行功能在237名后代的12岁时被评估,使用通过自我和照顾者报告的执行功能行为评级清单 (BRIEF-2).
多变量线性回归模型分析了日志转换的PBDE水平和BRIEF-2得分之间的关联,并按性别分层来评估效果的修改.

主要成果:

较高的妊娠期PBDE度与青少年执行功能缺陷的增加有关,由较高的BRIEF-2T分数表明.
特定的PBDE原体 (BDE-28,BDE-47,BDE-99) 和总结变量 (5BDE) 与各种执行功能领域显示出显著的关联.
关联在男性中通常更强,特别是在照顾者报告的执行功能措施中,这表明性别特异性影响.

结论:

孕期暴露于PBDE可能会对青春期后代的执行功能产生持久的不利影响.
这些发现凸显了与产前接触阻燃剂相关的神经发育风险,并强调了需要持续监测和监管的必要性.

关键词:

青少年是一个青少年.执行职能执行职能执行职能阻燃剂是一种阻燃剂.孕期的孕期的聚化二乙烯乙烯的多化二乙烯.

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