多样化的纳米载体设计,以优化氧化糖酶介导的抗瘤疗法:战略和进展
Yuhan Fu1, Jialin Sun2, Chunyu Yang3
1School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China; Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, Heilongjiang Province, China.
International journal of biological macromolecules
|March 1, 2025
概括
使用葡萄糖氧化酶 (GOx) 的饥饿疗法显示,通过向瘤葡萄糖,对癌症治疗有希望. 纳米载体输送系统正在开发中,以克服GOx的局限性并提高其对抗瘤的有效性.
科学领域:
- 生物医学工程 生物医学工程
- 在瘤学瘤学.
- 纳米技术纳米技术
背景情况:
- 瘤的复杂性和异质性限制了当前的癌症疗法.
- 使用葡萄糖氧化酶 (GOx) 的饥饿疗法 (ST) 针对瘤葡萄糖代谢.
- 基于蛋白质的GOx面临着不良稳定性和短的体内半衰期等挑战.
研究的目的:
- 审查纳米载体在瘤治疗中输送葡萄糖氧化酶的策略.
- 总结GOx介导癌症治疗的载体系统的进展情况.
- 分析基于GOx的疗法的挑战和未来方向.
主要方法:
- 系统地检查了三个关键的GOx交付策略:刺激-反应,生物膜修饰和本地交付.
- 为GOx.提供各种纳米载体系统的全面概述.
- 对现有挑战和未来研究途径进行批判性分析.
主要成果:
- 纳米载体提供了一个有效的平台,用于静脉注射和局部输送GOx.
- 在开发用于GOx介导瘤治疗的多种载体系统方面取得了进展.
- 提供了对纳米载体设计的见解,以改善GOx传递.
结论:
- 基于纳米载体的输送系统对于克服GOx在癌症治疗中的局限性至关重要.
- 需要进一步的研究来推进基于GOx的瘤治疗的开发和临床应用.
- 优化纳米载体设计对于增强GOx.治疗疗效至关重要.
更多相关视频
相关概念视频
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...