基于pullulan和HPMC的口服分解薄膜与碳聚涂层的粘膜粘合纳米颗粒用于双模式药物释放
Fariba Hashemi-Afzal1, Fariba Ganji1, Ebrahim Vasheghani-Farahani1
1Biomedical Engineering Department, Faculty of Chemical Engineering, Tarbiat Modares University, P.O. Box 14115-111, Tehran, Iran.
International journal of biological macromolecules
|March 1, 2025
概括
这项研究开发了一种新的双模式药物释放系统,通过将口服分解膜与粘粘性纳米颗粒相结合,实现立即和持续的米达佐拉姆释放. 这种创新系统表现出了出色的粘合力和可控的药物输送,而不会损害口腔粘膜.
科学领域:
- * 制药科学 制药科学
- * 材料科学 材料科学
- * 生物医学工程 * 生物医学工程
背景情况:
- *当前的药物输送系统往往难以平衡即时和持续释放的配置.
- *口服分解膜 (ODF) 提供快速的管理,而粘膜粘合纳米颗粒 (NP) 可以提供长时间的药物暴露.
- *米达佐拉姆 (MID) 是一种快速起作用的脂性药物,适合口腔分娩,但需要优化释放动力学.
研究的目的:
- * 开发和描述一种新的双模式药物释放系统,将ODF和粘粘性NP结合起来.
- *通过口服来实现米达佐拉姆 (MID) 的即时和持续释放.
- * 评估系统的粘粘度,药物释放特征和与口腔粘膜的生物相容性.
主要方法:
- *合成的含米达佐拉姆的丝纤维蛋白纳米颗粒,涂有碳聚合物 (MID-CP/SFNPs).
- *以大小,泽塔潜力和封装效率为特征的NP.
- *使用pullulan和hydroxypropyl甲基纤维素 (PUL/HPMC) 制造的ODF,通过造工艺将MID-CP/SFNP结合在一起.
- *评估了子口腔粘膜上的NP粘附性,并评估了最终的双系统的物理性质,药物释放动力学和组织学影响.
主要成果:
- *MID-CP/SFNP具有合适的尺寸 (260.3 nm),负泽塔电位 (-22 mV) 和高封装效率 (80.6%).
- *开发的双系统 (MID-CP/SFNPs@MID-ODFs) 显示了有利的特性:均厚度 (68.8微米),高药物含量 (87.5%),良好的灵活性 (219x) 和快速解体 (16秒).
- * 该系统实现了快速的初始释放 (30分钟内45.6%),随后持续释放,在20小时内释放了91%的MID,没有观察到对口腔粘膜组织学的不良影响.
结论:
- *成功开发了一种新的双模式药物递送系统,将粘膜纳米颗粒结合在口服分解膜中.
- * 这种系统有效地提供了立即和持续释放的米达佐拉姆,增强口腔药物输送.
- *该配方表现出优异的粘粘度和生物相容性,为先进的生物医学应用提供了一个有前途的平台.
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