不要排除你的观察:负皮质醇唤醒反应 (CAR) 可能是生物相关的
Jose F Herrera-Moreno1, Belem Trejo-Valdivia2, Maricruz Tolentino3
1Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA; Secretaría de Ciencia, Humanidades, Tecnología e Innovación (Secihti), Padrón de Investigadoras e Investigadores por, México.
Psychoneuroendocrinology
|March 2, 2025
概括
孕妇的阴性皮质醇唤醒反应 (CAR) 值可能表明潜在的健康问题或暴露. 研究人员应该分析这些负的CAR值,而不是将它们排除在压力研究之外.
科学领域:
- 内分泌学 在内分泌学.
- 环境健康 环境健康
- 血液学 血液学 血液学
背景情况:
- 皮质醇唤醒反应 (CAR) 是压力研究中的一个关键生物标志物,通常在醒来后呈现积极增加.
- 负的CAR值经常被排除在分析之外,但可能意味着潜在的健康状况或环境暴露.
- 已知 (Pb) 暴露会影响神经内分泌功能,包括皮质醇日间节律.
研究的目的:
- 调查怀孕妇女中负CAR值的流行情况.
- 检查阴性CAR值,血液学参数和血液中 (Pb) 水平 (BPb) 之间的关联.
主要方法:
- 900名孕妇的唾液皮质醇在两天内被测量,以计算CAR.
- 汽车被分为积极-积极 (CAR-PP),混合 (CAR-NP/PN) 和负-负 (CAR-NN) 组.
- 分析了全血细胞和血水平 (BPb);使用后勤回归来评估相关性.
主要成果:
- 37%的女性表现出CAR-NN,40%的女性表现出CAR-NP/PN,这表明经常出现负CAR值.
- 较高度的白细胞,氨基细胞,基细胞和BPb与负的CAR组 (CAR-NN和CAR-NP/PN) 有关.
- 与CAR-PP相比,阴性CAR组的女性与白细胞水平和更高的BPb度有相反的关联.
结论:
- 怀孕妇女的负CAR值可以作为健康或环境Pb暴露受损的指标.
- 在研究中考虑和彻底评估负的CAR值至关重要,而不是排除它们.
- 这项研究强调了负CAR在确定怀孕期间健康风险方面的潜在临床意义.
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