SARS-CoV-2 感染对金属恒温的长期影响
Luyao Zhang1, Fang Li2, Xiaoxiong Liu3
1State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.
概括
长期的COVID可能会导致必需金属水平的持久变化,甚至在感染后六个月也会影响新陈代谢和器官健康等身体功能. 这项研究揭示了康复患者的异常金属学特征.
科学领域:
- 环境科学 环境科学
- 生物化学 生物化学
- 公共卫生 公共卫生
背景情况:
- 随着COVID-19的流行,全球健康问题出现了重大变化.
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染的长期健康后果或后果是一个日益严重的公共卫生问题.
- 金属学概况可以提供对这些长期影响的见解.
研究的目的:
- 为了研究从SARS-CoV-2感染中恢复过来的个体的金属学概况.
- 为了确定SARS-CoV-2感染是否会导致基本和非基本金属度的持续变化.
- 探索COVID-19后金属学变化和代谢中断之间的关系.
主要方法:
- 进行了一项横截面研究,涉及25名康复的COVID-19参与者和38名健康对照.
- 测量了14种元素 (Fe, Cu, Zn, Se, Cr, Mn, Ba, Ni, Pb, Ag, As, Cd, Co 和 V) 的血清度.
- 进行了统计分析和金属体和代谢体之间的相关性分析.
主要成果:
- 与健康对照组相比,康复的参与者表现出改变的金属学特征,含量较高的Cu,Ag,As,Ba,Cd,Ni,Pb,Cr和V.
- 在康复的个体中发现Fe和Se度较低.
- 在大多数元素 (p < 0.05) 中观察到显著差异,因年龄和性别而异,表明金属平衡被破坏.
结论:
- SARS-CoV-2 感染可以导致金属恒温的长期干扰,在康复后至少持续六个月.
- 这些金属学变化与代谢过程受损有关,包括脂质代谢和细胞呼吸.
- 这些发现突显了COVID-19通过金属学调节障碍影响器官功能 (肝脏,脏,心脏) 的潜力.
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