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尿液中的草甘,状态及其对死亡率的影响:来自NHANES 2013-2018年的证据

Pei-Lun Chu¹, Ching-Chung Hsiao², Ta-Chen Su³

¹School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei 242, Taiwan; Department of Internal Medicine, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei 242, Taiwan.

Ecotoxicology and environmental safety

|March 2, 2025

概括

暴露于草甘与死亡风险增加有关,特别是在高水平的个体中. 的状态影响了这种风险,较低的含量显示出对抗草甘相关死亡的保护作用.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
营养流行病学营养流行病学

背景情况:

草甘和基于草甘的除草剂 (GBHs) 在全球广泛使用.
以前的研究表明,GBHs可能会破坏平衡.
在人口研究中,草甘暴露,状况和死亡风险之间的相互作用尚未得到充分理解.

研究的目的:

为了研究尿液中的草甘含量与全血之间的关系.
检查状态如何影响与草甘暴露相关的全因死亡风险.
分析来自美国全国代表性人口的数据.

主要方法:

从2013-2018年国家健康和营养检查调查 (NHANES) 的数据分析.
纳入6410名3岁及以上的参与者,对18岁及以上的18岁及以上人群进行死亡率随访至2019年.
复杂的多重线性回归模型来评估尿草甘,全血和摄入量之间的相关性;Cox对死亡风险的比例危险模型.

主要成果:

在尿液中的草甘和全血之间发现了显著的负相关性 (ß = -0.010,P=0.003).
尿液中较高的草甘水平与全因死亡风险增加有关 (HR=1.43),特别是在水平达到或超过第50百分位点的个体中.
较高的全血水平显示出对所有原因死亡率 (HR=0.01) 的保护作用,最明显的是在第50百分位以下的水平.

结论:

暴露于草甘与全血水平的改变有关.
在暴露于草甘的背景下,水平和死亡风险之间可能存在U形关系.
这些发现表明,草甘和相互作用可能对公共卫生产生影响,需要进一步调查.

关键词:

草甘是一种天然的草甘.基于草甘的除草剂 (GBH)死亡率死亡率死亡率国家健康和营养检查调查 (NHANES)摄入的摄入量整个血液中的是全血.

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