IL-5增强了人类巨细胞的存活率和对病毒感染的干扰素反应
Jasmine Barra1, Christopher R Liwski2, Phoebe Phonchareon1
1Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada; Beatrice Hunter Cancer Research Institute, Halifax, Nova Scotia, Canada.
The Journal of allergy and clinical immunology
|March 2, 2025
概括
干白素-5 (IL-5) 信号增强巨细胞干扰素的产生和病毒感染期间的生存. 这条涉及EPAS1的途径对于维持气道中大细胞种群至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 病毒学 病毒学
背景情况:
- 乳腺细胞是对粘膜感染的关键免疫哨兵.
- 呼吸道病毒感染与喘恶化和死亡率有关.
- 升高的IL-5 (IL-5) 与严重的形性疾病有关,这些疾病对IL-5阻塞有反应.
研究的目的:
- 为了研究IL-5信号在呼吸道病毒感染期间对巨细胞的影响.
- 阐明IL-5在巨细胞抗病毒反应和生存中的作用.
主要方法:
- 人类巨细胞被IL-5治疗,并感染了常见的呼吸道病毒 (OC43,RSV,reovirus).
- 测量了干扰素和干扰素刺激的基因表达.
- RNA测序分析了IL-5对巨细胞转录组的影响,并进行了功能验证.
主要成果:
- 治疗IL-5显著增加了巨细胞的干扰素产量.
- 通过对BCL2和EPAS1进行上调,IL-5促进了巨细胞的存活,从而防止了细胞亡.
- IL-5阻塞与喘患者外周血液中的EPAS1表达减少相关.
结论:
- IL-5信号选择性地增强质细胞干扰素反应.
- 一个新的IL-5/EPAS1轴在病毒感染期间维持巨细胞种群.
- 研究结果表明,IL-5阻断对腺细胞功能在喘中的影响.
相关概念视频
T Cell Types and Functions
774
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
774
Immune Response Against Viral Pathogens
725
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
725
Cell-mediated Immune Responses
66.7K
Overview
66.7K
Cytotoxic T Cells-mediated Immune Response
825
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
825
Differentiation of Common Myeloid Progenitor Cells
3.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.2K


