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Updated: May 24, 2025

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
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A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α

Published on: November 2, 2018

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IKAROS 蛋白质的稳定性是由其早期的 N 终端区域和 C 终端二元化域调节的

Natchanun Klangkalya1, Ana Esteve-Sole2, Agustin A Gil Silva2

  • 1Immunology Service, Department of Laboratory Medicine, NIH Clinical Center, NIH, Bethesda, MD, USA; Department of Pediatric, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Clinical immunology (Orlando, Fla.)
|March 2, 2025
PubMed
概括

影响蛋白质稳定性的IKAROS (IKZF1) 基因突变,特别是在前指1区域,导致免疫缺陷和疾病. 减少IKAROS稳定性导致哈普洛因不足并影响淋巴细胞功能.

关键词:
哈普洛因不足的情况在 IKZF1免疫的先天错误 免疫的先天错误主要免疫缺陷是一个主要的免疫缺陷.蛋白质的稳定性 蛋白质的稳定性转录因子 转录因子

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