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较高的PFOS暴露与第三季度较高的SHBG相关. 沉重的儿童队伍队列

Richard Christian Jensen¹, Dorte Glintborg², Erich Batzella³

¹Department of Endocrinology, Odense University Hospital, Søndre Blvd. 29, 5000, Odense C, Denmark; Department of Clinical Pharmacology, Pharmacy and Environmental Medicine, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark.

Environmental research

|March 2, 2025

概括

孕妇在怀孕期间暴露于 perfluorooctane sulfonic acid (PFOS) 与增加的性激素结合球蛋白 (SHBG) 水平有关. 这表明潜在的转向雌激素效应,影响胎儿发育.

科学领域:

内分泌学在内分泌学.
环境健康环境健康
生殖毒理学生殖毒理学

背景情况:

perfluoroalkyl物质 (PFAS) 是具有已知的雌激素作用的内分泌干扰化学物质.
PFAS可以诱导芳香酶活性,影响性激素平衡.
性激素结合球蛋白 (SHBG) 反映了雌激素和之间的平衡.

研究的目的:

检查孕妇PFAS度与妊娠期间SHBG和水平之间的关系.
研究特定的PFAS化合物,包括PFHxS,PFOS,PFOA,PFNA和PFDA.

主要方法:

对1611名孕妇妊娠12周PFAS度的分析.
在妊娠第29周的1048名女性中测量SHBG,自由 (Free-T),自由原体指数 (FAI) 和总 (TT).
利用多重线性回归和量子G计算来评估关联.

主要成果:

perfluorooctane sulfonic acid (PFOS) 度的翻倍与SHBG. 2.29%的增加相关.
与第一季度相比,第三季度的PFOS暴露显著增加了4.60%的SHBG.
在PFAS和总丸激素之间没有发现显著的关联;在Free-T和FAI中观察到非显著的反向关联.

结论:

孕妇接触PFOS与SHBG增加有关,这表明转向雌激素效应.
怀孕期间雌激素效应升高可能会影响后代的神经,代谢和内分泌发育.
需要对后代进行进一步的跟踪,以了解长期影响.

关键词:

发展性毒性发展性毒性 perfluoroalkyl 物质是一种高醇基物质.怀孕怀孕怀孕怀孕性激素结合型全球蛋白是一种性激素结合型全球蛋白.

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