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Updated: May 24, 2025

Detection of Mitochondria Membrane Potential to Study CLIC4 Knockdown-induced HN4 Cell Apoptosis In Vitro
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低细胞外pH值通过降低Mcl-1表达的调节来增强TRAIL诱导的亡

Farzaneh Vafaeinik1, Lin Zhang2, Yong J Lee1

  • 1Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.

Experimental cell research
|March 2, 2025
PubMed
概括

低的细胞外pH值显著增强与瘤亡因子相关的结直肠癌细胞中的亡诱导配体 (TRAIL) 细胞毒性. 这种效应是由Mcl-1下调和JNK激活的介导,这对于TRAIL诱导的亡至关重要.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.结肠直肠癌是一种癌症.低的细胞外pH值在MCL-1中,MCL-1是最常见的.轨道的轨道是一个轨道.

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