对西班牙裔和非西班牙裔男性进行的组织,液体和生殖基因检测的回顾性分析,这些男性患有晚期激素敏感前列腺癌
Aaron J Bertolo1, Ricardo J Estrada-Mendizabal2, Megan K Taylor1
1Department of Medicine, University of Arizona, Tucson, AZ.
Urologic oncology
|March 2, 2025
概括
患有前列腺癌的西班牙裔美国男性 (PCa) 患有更晚期的疾病和明显的基因组突变,包括TMPRSS2-ERG融合和TMB-High. 这些发现强调了为这个代表性不足的群体制定量身定制的查和治疗策略的必要性.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 健康差异 在健康上的差异
背景情况:
- 前列腺癌 (PCa) 显著影响美国男性,具有显著的种族和民族差异.
- 西班牙裔美国人 (HA) 在PCa基因组研究中代表性不足,尽管他们的疾病负担很大.
研究的目的:
- 研究西班牙裔美国人 (HA) 和非西班牙裔美国人 (NHs) 之间前列腺癌的基因组差异.
- 了解在代表性不足的HA人群中PCa健康差异的驱动因素.
主要方法:
- 对111名转移前列腺腺癌患者 (2015-2023) 的回顾性分析.
- 从组织,液体和生殖系样本的基因组数据与HA和NH患者队列之间的比较.
- 统计分析包括t测试,克鲁斯卡尔-瓦利斯,奇方,费舍尔的精确测试和卡普兰-梅尔方法.
主要成果:
- 西班牙裔美国人 (HA) 占研究队列的41%.
- HAs呈现出更高的PSA水平,更先进的病理阶段 (T4,M1c) 和更短的第一线治疗时间.
- 在HA中,TMPRSS2-ERG融合和TMB-High突变明显更普遍.
结论:
- 与非西班牙裔美国人相比,西班牙裔美国人PCa患者患有更晚期的疾病.
- 基因组差异,包括TMPRSS2-ERG融合和TMB-High突变,需要早期检测和个性化治疗HA.
- 扩大基因组研究和解决治疗差异对于改善这个代表性不足的人群的结果至关重要.
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