胆囊腺状癌:管理这种罕见实体的双机构经验
Gurudutt P Varty1, Shraddha Patkar1, Sujat Lele2
1Department of Gastrointestinal and Hepatopancreatobiliary Surgery, Department of Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
概括
包括手术和化疗在内的多模式治疗为腺状胆囊癌 (ASGBC) 提供了最佳的生存率. 早期的ASGBC有最好的预后,而转移性疾病是最糟糕的.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠道瘤学 胃肠道瘤学
背景情况:
- 腺状胆囊癌 (ASGBC) 是一种罕见的胆囊癌亚型,管理数据有限.
- 目前关于ASGBC治疗策略的研究很少,需要进一步调查.
研究的目的:
- 评估腺性胆囊癌 (ASGBC) 的管理和结果.
- 为了比较不同阶段的生存率和ASGBC的治疗方式.
主要方法:
- 在2012年1月至2022年3月期间被诊断出ASGBC的患者被分为早期,局部先进 (LA) 和转移 (M) 阶段.
- 根据治疗阶段和治疗方法 (手术与非手术) 分析了治疗结果,包括整体生存期 (OS).
主要成果:
- 总共分析了196名患者:早期9.7%,LA27%,转移性ASGBC63.3%.
- 转移性 (3.9个月) 的中位数是最糟糕的,早期ASGBC (未达到) 的最佳.
- 经过手术治疗的LA-ASGBC患者的1年和3年的生存率明显高于未经手术治疗的患者 (72.6%,35.6%与25.1%,0%,p <0.001).
结论:
- 多模式治疗,包括边缘阴性外科切除和术后化疗,在ASGBC中提供了长期生存的最佳机会.
- 虽然切除的ASGBC比切除的胆囊腺癌 (GBACs) 趋向于较低的中位 OS,但与相应阶段的GBAC相比,切除的ASGBC的III阶段显示出明显更差的OS.
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