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Updated: May 24, 2025

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染色体组合因子1亚单元A通过在癌细胞中招募E3泛素合酶RAD18来促进TLS途径

Bing Wen1, Hai-Xiang Zheng2, Jing-Hua Heng2

  • 1The Key Laboratory of Molecular Biology for the High Cancer Incidence Coastal Chaoshan Area, Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou, 515041, Guangdong, P.R. China.

Cell death & disease
|March 2, 2025
PubMed
概括

染色体组合因子1亚单元A (CHAF1A) 是癌细胞中转化DNA合成 (TLS) 的新型调节剂. CHAF1A通过促进复制重启和增殖细胞核抗原 (PCNA) 单双化来增强DNA损伤耐受性.

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