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一个关于含药PLGA微粒的配方参数和特征的数据集

Zeqing Bao^1,2, Jongwhi Kim¹, Candice Kwok¹

¹Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, M5S 3M2, Canada.

Scientific data

|March 2, 2025

概括

这项研究提供了用于持续药物释放的聚酸乳酸合糖化物 (PLGA) 微粒 (MP) 配方的综合数据集. 这些数据支持开发长效注射剂,改善慢性疾病管理和患者坚持治疗.

科学领域:

制药科学制药科学
生物材料工程生物材料工程
药物输送系统药物输送系统

背景情况:

聚合物微粒 (MP) 对于开发长效注射配方至关重要,使药物持续释放成为可能.
这种持续释放可以通过减少剂量频率和提高患者坚持治疗来改善慢性疾病的管理.
聚乳酸-协同甘油化物 (PLGA) 是商用基于微粒的药物制品中主要使用的聚合物.

研究的目的:

从现有文献中编制PLGA微粒 (MP) 配方的综合数据集.
为研究人员和开发人员在长效注射配方领域提供宝贵的资源.
促进数据驱动的方法,包括机器学习,以简化MP设计和开发.

主要方法:

挖掘文献,从321个体外释放研究中提取数据.
包括在PLGA微粒中配制的89种不同药物的数据.
数据集的编制集中在与微粒子配方和药物释放相关的参数上.

主要成果:

一个精心策划的数据集,详细介绍了PLGA微粒在体外释放的321项研究.
数据集涵盖了89种不同药物的广泛范围,反映了各种治疗应用.
汇编的数据代表了PLGA微粒子配方的当前设计空间.

结论:

开发的数据集是推动基于PLGA微粒的药物递送系统的基础资源.
它旨在加快新型长效注射配方的设计和开发.
开放式获取出版物鼓励广泛使用,以扩大可用的微粒子配方库.

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