在2型糖尿病患者中,FT4/FT3比率与微专尿之间存在关联
Hongyan Zhao1,2, Xuan Ma1,2, Shuwei Shi1,2
1School of Clinical Medicine, Shandong Second Medical University, Weifang, 261000, Shandong, China.
Scientific reports
|March 2, 2025
概括
自由甲状腺素 (FT4) 与自由三甲状腺素 (FT3) 的比率与2型糖尿病中微专尿 (MAU) 有关. 更高的FT4/FT3比率表明MAU的风险增加,这表明损伤的潜在标志物.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學.
- 糖尿病学 糖尿病学
背景情况:
- 微专尿 (MAU) 是糖尿病病 (DKD) 和全身血管内皮损伤的预测因素.
- 甲状腺激素 (TH) 与心血管疾病和内皮功能障碍有关.
- 在2型糖尿病 (T2DM) 中,自由甲状腺素 (FT4) 与自由三甲状腺素 (FT3) 的比率和MAU之间的关联需要进一步研究.
研究的目的:
- 调查FT4/FT3比率与T2DM无甲状腺患者的MAU之间的关联.
主要方法:
- 总共有1734名无甲状腺T2DM患者被纳入.
- MAU被定义为30至300毫克/克之间的尿白蛋白与肌素比率 (UACR).
- 进行了统计分析,包括单变量和多变量回归,以评估FT4/FT3比率和MAU之间的关系.
主要成果:
- 与正常白蛋白尿症 (NAU) 组相比,MAU组的FT4/FT3比率显著更高 (P < 0.001).
- 在单变量分析中,FT4/FT3比率与UACR和MAU都有积极关联 (P < 0.001).
- FT4/FT3比率独立预测了UACR (标准化系数:0.148,P<0.001),并成为MAU的独立风险因素 (赔率比:1.947,95%CI:1.522-2.491).
结论:
- FT4/FT3比率与T2DM无甲状腺患者的MAU独立且正相关.
- 这一比率可以作为一种有价值的指标,用于早期检测T2DM患者的损伤.
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