早期生命大脑网络连接 执行功能的先例 在早产儿中
Abiot Y Derbie1, Mekibib Altaye2,3, Junqi Wang4
1Neurodevelopmental Disorders Prevention Center, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Communications biology
|March 2, 2025
概括
过早分娩会影响执行功能 (EF),因为大脑连接性发生变化. 岛屿和关键融合中心中更有效的结构路径与早产婴儿的更好的EF结果有关.
科学领域:
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
- 认知科学 认知科学
背景情况:
- 过早分娩 (怀孕期 ≤ 32 周) 是执行功能 (EF) 缺陷的重要危险因素.
- 在早产婴儿中这些EF缺陷的神经支仍然不完全理解.
- 在术语相当年龄 (TEA) 了解大脑连接对于预测以后的认知结果至关重要.
研究的目的:
- 为了研究结构连接 (SC) 和功能连接 (FC) 在TEA和EF表现之间的关系,在早产婴儿的3岁校正年龄.
- 阐明神经机制,将早产后的大脑发育与认知功能联系起来.
主要方法:
- 在TEA的早产婴儿中利用扩散MRI和休息状态功能MRI.
- 应用图形理论分析来量化SC和FC网络属性.
- 与EF结果的相关网络指标在3岁时进行评估.
主要成果:
- 岛内较短的平均路径长度 (增强的结构通信) 与更好的EF相关.
- 在平顶部和上部区域 (关键集成枢纽) 之间更高的中心性与更好的EF相关.
- 多模式分析表明,SC效率影响FC组织,突出显示白质在塑造功能枢纽中的作用.
结论:
- 结构性大脑效率,特别是在岛内,在支持早产儿执行功能方面发挥着至关重要的作用.
- 早期结构连接的中断可以改变对EF发展至关重要的后续功能连接模式.
- 节点级网络指标提供了精确的洞察力,了解SC如何引导FC关系,这对于认知结果至关重要.
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