在同卵双胞胎的不良子宫内情况后,新生儿心声学上的早期结构性心血管变化
Sophie G Groene1,2, Erik W van Zwet3, Arend D J Ten Harkel4
1Neonatology, Willem-Alexander Children's Hospital, Dept. of Pediatrics, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, the Netherlands. S.G.Groene@lumc.nl.
Pediatric research
|March 2, 2025
概括
胎儿生长限制 (FGR) 影响心血管发育. 在同卵双胞胎中,较小的双胞胎心脏较小,但心脏结构受到影响较小,比身体大小小小,这表明早期编程心血管疾病.
科学领域:
- 新生儿心脏病学 新生儿心脏病学
- 胎儿编程 胎儿编程是一种
- 进行心血管改造.
背景情况:
- 之前关于心血管变化后胎儿生长限制 (FGR) 的研究仅限于将FGR新生儿与适当成长的新生儿进行比较.
- 这项研究调查了FGR早期的结构性心血管改造,使用同卵双胞胎来控制遗传和母亲因素.
研究的目的:
- 评估经历生长限制的胎儿早期结构性心血管变化.
- 利用独特的双胞胎研究设计来隔离FGR对心血管发育的影响.
主要方法:
- 从2019年1月开始,对单双胞胎进行前性队列研究.
- 在出生后一周内进行的胸前回声心脏成像.
- 较小和较大的双胞胎之间的心脏结构z-score的比较,考虑到妊娠年龄.
主要成果:
- 包括100对双胞胎,平均妊娠年龄为33.8周.
- 与较大的双胞胎相比,较小的双胞胎对所有心脏结构的z分数较低.
- 较小的双胞胎出生体重的偏差比心脏结构的偏差更明显.
结论:
- 出生时体重较低的同卵双胞胎在新生儿心声学上表现出较小的心脏结构.
- 心脏结构受到FGR的影响比整体身体大小相对较小.
- 研究结果表明,由于不良子宫内条件导致的心血管疾病的早期心血管改造和胎儿编程.
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