基因预测的血代谢物调解了肠道微生物群和骨髓瘤之间的因果关系
Xiuyu Qin1, Zhuming Fan2, Shaopeng Qiao2
1Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Scientific reports
|March 2, 2025
概括
肠道微生物群 (GM) 和血代谢物影响骨肉瘤 (OS) 风险. 这项研究使用了门德尔的随机化,揭示了Phocea作为OS的因果转基因,Eugenol硫酸盐和N-乙烯基氨酸调解了这种联系.
科学领域:
- 遗传学和奥米克学
- 代谢学 代谢学 代谢学
- 在瘤学瘤学.
背景情况:
- 肠道微生物群 (GM) 的变异与骨髓瘤 (OS) 的发展有关.
- 涉及转基因,血代谢物和OS的确切因果途径在很大程度上仍未被阐明.
- 了解这些关系对于确定OS的新疗法目标和预防策略至关重要.
研究的目的:
- 使用孟德尔的随机化 (MR) 方法,研究肠道微生物群,血代谢物和骨肉瘤 (OS) 之间的因果关系.
- 为了确定特定的肠道细菌和与OS风险因果相关的血代谢物.
- 探索血代谢物在肠道微生物群和OS之间的因果关系中的潜在调解作用.
主要方法:
- 采用两样和两步的门德尔随机化 (MR) 分析,利用大规模的全基因组关联研究 (GWAS) 数据对转基因,血代谢物和OS.
- 使用逆方差加权 (IVW) 方法作为主要分析,并使用加权中位数,MR-Egger和其他灵敏度分析来评估因果关系.
- 通过MR-Egger拦截和MR-PRESSO评估状性,并通过Cochran的Q测试和离开一个分析评估异质性.
主要成果:
- 确定了13种转基因类型与OS的潜在因果关系,在FDR校正后,Phocea被证实是显著的因果因素.
- 发现了48种血代谢物,包括已知和新型化合物,与OS有因果关系.
- 揭示了尤根醇硫酸盐 (7.74%调解) 和N-乙 fenylalanine (3.52%调解) 可能调解Phocea和OS之间的因果关系.
结论:
- 这项MR研究确定了特定的肠道微生物群,血代谢物和骨髓瘤 (OS) 之间的因果关系.
- 突出了Phocea作为关键的肠道细菌,与OS发展有关.
- 证明了Eugenol硫酸盐和N-乙 fenylalanine在Phocea-OS轴中的调解作用,表明了潜在的生物标志物和治疗点.
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