超加工食品,遗传倾向和结石风险:基于人口的前性队列研究
Song Bai1, Yixiao Zhang1, Yashu Liu2
1Department of Urology Surgery, Shengjing Hospital of China Medical University, China Medical University, Shenyang, China.
European journal of nutrition
|March 2, 2025
概括
更高的超加工食品 (UPF) 摄入量与结石风险增加有关,特别是在具有较低遗传倾向的个体中. 公共卫生战略应考虑减少UPF消费以预防结石.
科学领域:
- 营养流行病学 营养流行病学
- 腎臟病學 (nephrology) 是一種醫學.
- 遗传学 是一个遗传学.
背景情况:
- 超加工食品 (UPF) 消费与结石风险之间的关联尚未得到充分研究.
- 遗传倾向对这种潜在关联的影响仍然不清楚.
研究的目的:
- 调查UPF摄入量与结石风险之间的关系.
- 通过多基因风险评分 (PRS) 评估的遗传倾向在这种协会中的作用.
- 探索UPF消费与结石遗传风险之间的潜在相互作用.
主要方法:
- 利用了来自166427名中年参与者的英国生物库数据.
- 使用NOVA分类系统和24小时饮食回忆评估UPF摄入量.
- 计算了结石特异性多基因风险评分 (PRS) 并使用了考克斯比例危险回归.
主要成果:
- UPF的消费与结石风险有积极的关联 (P < 0.01).
- 在UPF摄入量最高的三分之一的参与者与最低的参与者相比,风险增加了24%.
- 从UPF中排除酸奶和谷物进一步放大了风险 (HR: 1.32).
- 这种联系在患有低至中等PRS的人群中更为明显,而不是高PRS的人群.
- 高的UPF消费和高的PRS联合显著增加了结石的风险 (HR:1.95).
结论:
- 更高的超加工食品消费与患结石的风险增加有关.
- 调查结果表明,公共卫生政策应该旨在减少UPF摄入量以预防结石.
- 需要进一步的干预研究来验证这些流行病学发现.
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