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全球和人口特异性的MTHFR多态与早产风险的关联:对44项研究的综合分析

Maryam Vafapour¹, Hanieh Talebi², Mahsa Danaei³

¹Department of Pediatrics, Firoozabadi Clinical Research Development Unit, Iran University of Medical Sciences, Tehran, Iran.

BMC pregnancy and childbirth

|March 2, 2025

概括

MTHFR C677T基因变异与早产风险增加有关,特别是在亚洲和印度人群中. 该MTHFR A1298C变种没有显著的关联与早产风险.

科学领域:

遗传学是一个遗传学.
生殖健康生殖健康
流行病学流行病学

背景情况:

调查了甲基四叶酸减少酶 (MTHFR) 基因多态和早产风险 (PTB) 之间的关联.
MTHFR基因变异与叶酸代谢有关,可能会影响怀孕的结果.

研究的目的:

进行元分析,评估MTHFR基因多态 (C677T和A1298C) 与PTB风险之间的关系.
探索这一遗传关联中的特定人群差异.

主要方法:

使用PubMed,Web of Science和CNKI进行了全面的文献审查,并于2025年1月1日完成.
包括44个病例控制研究 (7,384个病例,51,449个控制) 分析MTHFR C677T和A1298C多态.
在元分析中,使用几率比率 (OR) 和95%置信区间 (CI) 来量化关联.

主要成果:

在多个遗传模型 (异位基因,同位基因,异位基因,主导性,衰退性) 中发现了MTHFR C677T多态性和PTB风险之间的显著关联.
亚组分析显示,亚洲人群 (中国,印度) 中存在显著的关联,但高加索人群中没有.
在MTHFR A1298C多态和PTB风险之间没有发现显著的关联.

结论:

MTHFR C677T多态性是PTB的重要危险因素,特别是在亚洲和印度人群中.
MTHFR A1298C多态性似乎没有显著影响PTB风险.
人口特有的遗传因素对于了解PTB的流行病学至关重要.

关键词:

种族的变异性民族的变异性遗传多形态的遗传多形态.这就是MTHFR基因.怀孕并发症怀孕并发症过早分娩过早分娩是什么

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