从癌症患者中分离出的细菌病原体的抗微生物耐药性:系统性审查和元分析
Onyansaniba K Ntim1, Aaron Awere-Duodu1, Abdul-Halim Osman1
1Department of Medical Microbiology, University of Ghana Medical School, P.O. Box, Accra, KB, 4236, Ghana.
BMC infectious diseases
|March 2, 2025
概括
在全球范围内,来自癌症患者的细菌中,抗菌素耐药性 (AMR) 高得令人担忧. 这突显了对更好的感染控制和抗生素在癌症治疗中的使用的迫切需要.
科学领域:
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
- 微生物学 微生物学
背景情况:
- 抗微生物药物耐药性 (AMR) 构成了严重的全球健康威胁,限制了感染治疗选择.
- 癌症患者面临抗生素耐药性感染的风险增加,使得AMR在这个人群中特别重要.
- 本综述全面分析了全球影响癌症患者的关键细菌病原体中的AMR患病率.
研究的目的:
- 从癌症患者中分离出的主要细菌病原体中对抗菌素耐药性的流行情况进行系统审查和综合数据.
- 为了确定特定的细菌物种和抗菌素耐药性模式,在这个脆弱的患者群体中最为关注.
主要方法:
- 在PubMed,Scopus和Web of Science进行了广泛的文献搜索,寻找2000年至2024年间发表的研究.
- 用单组元分析量化癌症患者中发现的主要细菌物种的耐药性流行率.
主要成果:
- 该审查包括132篇全文文章,重点关注血液癌症患者 (36.4%).
- 在关键病原体中观察到高耐药率:大肠杆菌 (81.84%对青素),Klebsiella肺炎 (98.99%对青素),Acinetobacter baumannii (例如84.10%对第三代头素),Enterococcus faecium (90.64%对青素).
- 逃生病原体,包括大肠杆菌,肺炎,黄金,A. baumannii,P. aeruginosa和E. faecium,对多种类型的抗生素表现出显著的耐药性.
结论:
- 在全球范围内,来自癌症患者的细菌病原体中,抗菌素耐药性的高流行率是显而易见的.
- 实质性的耐药性,特别是在ESKAPE病原体中,需要在全球癌症护理环境中立即改善感染预防和抗菌药物管理.
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