处方模式表明,在进行激进前列腺切除术后,对治疗勃起功能障碍的需求很高
Signe Benzon Larsen1, Annika Von Heymann2, Hein V Stroomberg3
1Department of Urology, Urological Research Unit, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark; Cancer Survivorship, Danish Cancer Institute, Copenhagen, Denmark; Section of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. signebenzonlarsen@gmail.com.
Acta oncologica (Stockholm, Sweden)
|March 3, 2025
概括
治疗勃起功能障碍的处方在急性前列腺切除术后显著增加. 神经节约手术影响了处方率,凸显了前列腺癌幸存者性功能障碍的集中管理的需要.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 激进前列腺切除术是前列腺癌的常见治疗方法.
- 勃起功能障碍 (ED) 是激进前列腺切除术的重要副作用.
- 固酶-5抑制剂是前列腺切除术后ED的主要治疗方法.
研究的目的:
- 为了调查激进前列腺切除术后的ED处方率.
- 在这个患者群体中确定影响ED处方率的因素.
主要方法:
- 丹麦前列腺注册局 (DanProst) 和丹麦处方注册局 (1995-2021) 数据的回顾性分析.
- 包括接受激进前列腺切除术,积极监测或非恶性活检的男性.
- 针对ED药物的处方比例和几率比率 (ORs) 的计算 (ATC:G04BE).
主要成果:
- 与对照组相比,在急性前列腺切除术的男性中,在活检后观察到ED处方的显著增加.
- 以前有ED处方的男性,新处方的可能性增加了3.49倍.
- 与双边神经节约手术相比,单边神经节约手术 (OR 1.23) 和无神经节约手术 (OR 0.40) 与不同的处方风险有关.
结论:
- 在急性前列腺切除术后,对ED治疗的需求很高.
- 前列腺癌幸存者代表着需要专注临床关注的大量人群来管理ED.
- 手术方法,特别是神经节约技术,影响ED治疗模式.
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