根据性结肠炎相关癌症的疾病持续时间的临床特征
Hiroshi Miyakita1, Seiichiro Yamamoto1, Motoi Uchino2
1Department of Surgery, Tokai University School of Medicine, Isehara, Japan.
概括
性结肠炎的持续时间会影响结肠炎相关的癌症特征,但不会影响预后. 早期诊断和特定的组织学类型更常见,疾病持续时间更长,尽管生存结果仍然相似.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 结肠直肠手术 结肠直肠手术
背景情况:
- 性结肠炎 (UC) 与结肠炎相关的癌症 (CAC) 有关.
- CAC通常呈现为平面类型,粘膜性癌症或印章环细胞癌.
- 需要进一步调查UC持续时间对CAC结果的影响.
研究的目的:
- 研究性结肠炎持续时间对结肠炎相关癌症临床病理特征的影响.
- 分析疾病持续时间如何影响CAC的诊断机会,组织学类型和瘤特征.
主要方法:
- 分析了1200名患有结直肠癌的UC患者的数据.
- 检查了组织学和临床病理学特征.
- 用5年和15年的疾病持续时间截止值进行了比较.
主要成果:
- 在疾病持续时间 (0-5 vs. >5年) 和诊断机会,血管侵入,N因子,病态阶段和瘤位置之间发现了显著的相关性.
- 较长的疾病持续时间 (>15年) 与诊断机会和原发性硬化胆道炎相关.
- 趋势分析显示了疾病持续时间和诊断机会,组织学类型,血管入侵和瘤位置之间的相关性.
结论:
- 随着UC持续时间的增加,CAC的独特组织学和临床特征会出现.
- 这些特征随着时间的推移而加剧,但似乎没有显著改变预后结果.
- 目前的发现表明,在癌症治疗决策中,区分短期和长期的疾病持续时间可能不必要.
更多相关视频
相关概念视频
Inflammatory Bowel Disease I: Ulcerative Colitis
112
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
112
Chronic Bowel Disorders: Introduction
376
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
376
Inflammatory Bowel Disease II: Crohn's Disease
157
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
157
Cancer Survival Analysis
319
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
319
Peptic Ulcer Disease I: Introduction
114
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
114
Drugs for Treatment of Ulcerative Colitis in IBD
116
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
116


