血动脉动原体指数升高与心脏orenal综合征患病率增加有关:一个横截面研究
Sikai Xu1, Jianping Hu2, Zhiyi Ouyang3
1Department of Medical Genetics, the Second Affiliated Hospital of Nanchang University, Nanchang, China.
Renal failure
|March 3, 2025
概括
较高的血动脉质指数 (AIP) 与心脏脏综合征 (CRS) 风险增加有关. 这种关联在没有高血压的个体中更为强烈,这表明AIP是CRS的潜在生物标志物.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
- 生物标志物 生物标志物
背景情况:
- 心脏病综合征 (CRS) 涉及同时发生的心脏和脏功能障碍.
- 血的无原体指数 (AIP),由甘油三 (TG) 和高密度脂蛋白胆固醇 (HDL-C) 衍生,是一种潜在的心血管风险标志物.
研究的目的:
- 调查AIP和CRS之间的关联.
- 探索AIP和CRS在大量人口队列中的潜在联系.
主要方法:
- 利用了来自全国健康和营养检查调查 (2005-2018) 的数据,其中有35,365名参与者.
- 通过同时存在的心血管疾病 (CVD) 和慢性病 (CKD) 定义的CRS.
- 采用加权后勤回归和限制立方线 (RCS) 分析,对共变量进行调整.
主要成果:
- 在所有模型中观察到AIP和CRS之间的正相关性.
- 最高AIP四分位数显示CRS的几率比率 (OR) 显著增加 (OR = 1.62).
- RCS分析证实了AIP-CRS的正相关性;TG与CRS的正相关性,HDL-C与CRS的负相关性. 观察到与高血压的显著相互作用,非高血压个体的相关性更强.
结论:
- 较高的AIP水平与较高的CRS患病率有关.
- 该研究强调了与高血压的显著相互作用,表明AIP对非高血压个体的CRS的影响更大.
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