视觉敏度与发生动脉样性心血管疾病之间的关联:调解者的纵向测试
Zijing Du1, Xiayin Zhang1, Gabriella Bulloch2
1Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Global heart
|March 3, 2025
概括
视力敏度 (VA) 的恶化与动脉样硬化心血管疾病 (ASCVD) 事件的风险更高有关. 管理抑郁症,高血压和糖尿病等疾病可能有助于降低这种风险.
科学领域:
- 眼科和心血管医学.
- 公共卫生和流行病学
- 生物医学数据科学 生物医学数据科学
背景情况:
- 视力敏度 (VA) 和动脉样硬化心血管疾病 (ASCVD) 事件之间的潜在关系仍未得到充分研究.
- 了解VA-ASCVD协会中的潜在调解者对于有针对性的干预至关重要.
研究的目的:
- 调查视力敏度 (VA) 和动脉样硬化心血管疾病 (ASCVD) 事件之间的潜在关联.
- 检查高血压,糖尿病,抑郁症和社会经济地位在VA-ASCVD关系中的调解作用.
主要方法:
- 使用110,522名参与者的英国生物库数据进行的前性队列研究,具有基线VA测量 (logMAR图).
- 使用考克斯比例危险模型分析VA和事件ASCVD事件 (住院,死亡记录) 之间的纵向关联.
- 四向分解调解分析量化了关键潜在调解者的间接影响.
主要成果:
- 在11.13年的中位数随访期间,VA的单线恶化 (0.1 logMAR增加) 与ASCVD风险增加 (HR = 1.63; P < 0.001) 有显著关联.
- 高血压 (3.8%),糖尿病 (3.3%),社会经济地位 (5.9%) 和抑郁症 (5.7%) 显著调解了VA与ASCVD的关联.
- 抑郁症成为最强的调解因素,占女性相关性的10.0% (P < 0.05).
结论:
- 视力下降是增加ASCVD风险的重要预测因素.
- 建议定期进行眼科检查,以便在中老年和老年人中早期发现和降低ASCVD的风险.
- 心理健康,特别是抑郁症,在视力敏度和ASCVD之间的关系中起着关键作用,特别是在女性中.
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