CCL11 (Eotaxin) 促进与衰老相关的心血管疾病的进展
Tanwei Zhang1, Yanhong Huang1, Xinmeng Ji1
1Key Laboratory of Targeted Intervention of Cardiovascular Disease and Collaborative Innovation Center for Cardiovascular Translational Medicine, Department of Pathophysiology, Nanjing Medical University, 211166 Nanjing, Jiangsu, China.
Reviews in cardiovascular medicine
|March 3, 2025
概括
慢性炎症与衰老疾病有关. 本综述探讨了血清C-C-基因化学因配体11 (CCL11) 以及它在衰老中的作用,特别是在心血管疾病 (CVD) 中.
科学领域:
- 老年学是指老年学的学科.
- 免疫学 免疫学 免疫学
- 心血管医学 心血管医学
背景情况:
- 与衰老相关的疾病,包括心血管疾病 (CVD),神经退行和癌症,在老年人中显著影响寿命.
- 慢性炎症反应与与衰老相关疾病的发展和进展密切相关.
- 一个使用血液免疫生物标记物的深度学习的炎症衰老时钟 (iAGE) 已经确定了与衰老疾病相关的诸如血清C-C-动机化学因子联接体11 (CCL11) 等因素.
研究的目的:
- 审查慢性炎症和衰老过程之间的关系.
- 总结血清C-C-动机化学酶联体11 (CCL11) 在与衰老相关的疾病中的作用.
- 具体讨论将CCL11与心血管疾病 (CVD) 联系起来的潜在机制.
主要方法:
- 文献综述,重点关注慢性炎症,衰老和与衰老相关的疾病.
- 对神经退行性疾病和心血管疾病 (CVD) 中的血清C-C-动机化学因配体11 (CCL11) 现有研究的分析.
- 讨论基于深度学习的炎症衰老钟 (iAGE) 发现.
主要成果:
- 根据iAGE模型的预测,血清C-C-动机化学因配体11 (CCL11) 与与衰老相关的疾病之间存在正相关性.
- 越来越多地报道了CCL11在神经退行性疾病中的作用.
- 观察到CCL11和心血管疾病 (CVD) 之间的正相关性,尽管潜在的机制需要进一步研究.
结论:
- 慢性炎症是衰老和相关疾病的关键因素.
- 血清C-C-动机化学因子配体11 (CCL11) 与与衰老相关的疾病有关.
- 需要进一步的研究来阐明CCL11对心血管疾病 (CVD) 的贡献机制.
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