对于链球菌血流感染的治疗时间短或长
Julie Gray1, Chong Zhang2, Ali Earl3
1Department of Pharmacy, Yale New Haven Health, New Haven, CT, USA.
概括
较短的抗生素持续时间似乎是安全的不复杂的链球菌血流感染 (BSI). 这项研究发现,短期和长期抗生素疗程之间的结果,如复发性BSI或死亡率没有显著差异,这表明更短的持续时间可能是合理的.
科学领域:
- 传染性疾病 传染性疾病
- 抗微生物药物管理委员会
- 临床结果研究研究
背景情况:
- 抗菌素耐药性的增加需要更短的抗生素持续时间.
- 证据支持格拉姆阴性血流感染 (BSI) 的较短疗程.
- 有限的数据存在于Streptococcal BSI治疗时间.
研究的目的:
- 为了比较短期和长期抗生素治疗不复杂的链球菌BSI的临床结果.
- 在这个患者群体中评估减少抗生素治疗时间的安全性和有效性.
主要方法:
- 犹他大学卫生部的回顾性队列研究.
- 用于分析抗生素持续时间 (≤10天与>10天) 的治疗权重的逆概率 (IPTW).
- 主要结局:复发性BSI,所有原因死亡率和30天再入院的组合.
主要成果:
- 分析了196名没有并发症的链球菌BSI患者.
- 平均持续时间:8天 (短) 和15天 (长).
- 在短时间和长时间的抗生素治疗之间,复合结果没有显著差异 (18%对18%;OR=1.42).
结论:
- 在Streptococcal BSI.短时间和长时间抗生素治疗之间没有显著的结果差异.
- 由于绝对事件率较低,更短的持续时间可能是合理的考虑因素.
- 需要进一步的研究来证实这些发现.
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