在严重的COVID-19感染后,与Candida相关的脏乳头结核
Ranjani Ravi1, Aravind Reghukumar2, Vimala A1
1Nephrology Cosmopolitan Hospital, Thiruvananthapuram, Kerala, India.
Journal of Brown hospital medicine
|March 3, 2025
概括
菌相关的 papillary necrosis 是一种罕见的脏并发症. 这项研究强调了其在最近患有严重COVID-19和免疫抑制的患者中发生的情况,这表明它与免疫系统变化有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 菌相关的 papillary necrosis 是一种罕见的疾病,通常在患有候选血症的免疫功能低下个体中见到.
- 此前关于这种情况的文献有限,记录的病例很少.
研究的目的:
- 在有严重COVID-19病史和免疫抑制治疗的患者中报告两例与Candida相关的脏 papillary necrosis.
- 探索COVID-19,免疫抑制和这种罕见的真菌脏疾病的发展之间的潜在关联.
主要方法:
- 两名患者的病例报告呈现出水尿基缩症.
- 在这两位患者中确认了与Candida相关的胞亡的诊断.
- 治疗包括双J支架和用可纳进行抗真菌治疗.
主要成果:
- 一名患有Candida相关胞亡的患者完全康复.
- 第二名患者,他先前患有4期慢性病,在随后的细菌性败血症发作后,进展为透析依赖的功能衰竭.
- 这两名患者都有严重的COVID-19病史,并服用免疫抑制剂.
结论:
- 与Candida相关的 papillary necrosis的发生率可能受到COVID-19的免疫调节效应和/或免疫抑制治疗的影响.
- 这种情况需要在患有阻塞性尿路病变的相关风险因素的患者中考虑.
- 需要进一步的研究来阐明连接COVID-19,免疫抑制和真菌脏感染的确切机制.
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