金属网络通过激发氧化和蛋白质毒性压力,专门消除缺氧瘤
Jia Liu1,2,3, Zuoyu Chen4, Lixue Deng1,5
1Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Bioactive materials
|March 3, 2025
概括
研究人员开发了CuGI,这是一种新的纳米疗法,通过改变其新陈代谢来向并消除缺氧癌细胞. 这种方法对治疗固体瘤和增强癌症治疗有希望.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 癌症研究 癌症研究
背景情况:
- 缺氧在固体瘤中很常见,阻碍了癌症治疗的有效性.
- 目前对缺氧瘤的临床策略有限.
- 向瘤缺氧对于改善癌症治疗结果至关重要.
研究的目的:
- 开发一种向和消除缺氧癌细胞的纳米治疗剂.
- 调查开发的药剂的作用机制.
- 在临床前模型中评估药物的疗效和生物相容性.
主要方法:
- 使用表甲基酸盐和铜离子制造金属网 (CuGI).
- 调查CuGI对低氧癌细胞代谢途径的影响.
- 评估活性氧物种的产生和蛋白质的寡合化.
- 在缺氧癌细胞中评估亡和cuproptosis诱导.
- 制备和测试癌细胞膜涂层CuGI (CuGI@CM) 的瘤透和有效性.
- 用血管干扰剂和放射治疗进行组合治疗的研究.
主要成果:
- 在缺氧癌细胞中,CuGI有效地将新陈代谢从糖解转向氧化酸化.
- CuGI增强了反应性氧物种的产生,并促进了脂质化蛋白质的寡合化.
- 在低氧癌细胞中,CuGI选择性地诱导了亡和亡,节省了正常细胞.
- CuGI@CM证明了瘤透的改善,并抑制了结直肠瘤的生长.
- 当与加剧瘤缺氧的疗法相结合时,CuGI@CM显示出协同效应.
结论:
- CuGI是一种强大的纳米治疗剂,专门针对和消除缺氧瘤.
- 在癌症治疗中,CuGI提供了一种有希望的策略来解决瘤缺氧问题.
- CuGI具有组合疗法的潜力,以提高整体癌症治疗疗效.
更多相关视频
19:44Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
Published on: May 30, 2012
18.7K
09:01Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
Published on: May 22, 2020
3.0K
相关概念视频
01:16Necrosis
3.9K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
3.9K
02:26Protein Networks
3.9K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
3.9K
01:46Electron Transport Chain: Complex I and II
10.1K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
10.1K
02:53Adaptive Mechanisms in Cancer Cells
5.7K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.7K
02:17The Tumor Microenvironment
6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K
02:49Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K