使用Pediococcus pentosaceus制备的豆奶酸奶TOKAI 759m通过调节高脂肪饮食小鼠的肠道微生物群来改善认知功能
Yuki Nakashima1,2, Tomoyuki Hibi1,3, Masafumi Urakami4
1Graduate School of Bioscience, Tokai University, 871-12 Sugido, Mashiki-machi, Kamimashiki-gun, Kumamoto, Japan.
Current research in food science
|March 3, 2025
概括
含有Pediococcus pentosaceus TOKAI 759m的豆奶酸奶可以通过调节肠道微生物群和减少炎症性细胞因子,预防高脂肪饮食小鼠的认知衰退和神经炎症.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 营养 营养 营养 营养 营养
背景情况:
- 肥胖与神经炎症和认知能力下降有关.
- 高脂肪饮食 (HFD) 会加剧这些情况.
- 益生菌干预显示了减轻饮食诱导病理的潜力.
研究的目的:
- 调查用Pediococcus pentosaceus TOKAI 759m制备的豆奶酸奶 (SY) 是否可以预防小鼠HFD时的认知衰退和神经炎症.
- 探索SY对肠道微生物群组成和炎症标志物的影响.
主要方法:
- 给小鼠提供正常饮食或HFD补充大豆牛奶 (SM),大豆牛奶酸奶 (SY) 或细菌细胞 (BC) 15周.
- 用新型物体识别测试来评估认知功能.
- 测量了血清和海马体中的炎症性细胞因子 (IL-6,TNF-α).
- 进行了海马体蛋白质组分析和便16SrRNA测序.
- 试验室研究评估了SY成分对微质细胞的影响.
主要成果:
- 与HFD组相比,SY组在新型物体识别测试中表现更好.
- 消费SY导致海马体IL-6和TNF-α水平降低.
- SY摄入量倾向于增加产生丁酸盐的细菌的比例 (例如,Clostridium,Akkermansia).
- 在体外,SY成分降低了微质细胞中的炎症性细胞因子水平.
结论:
- 用P. pentosaceus TOKAI 759m制备的豆乳酸奶可以预防HFD诱导的认知衰退和神经炎症.
- 保护作用可能通过肠道微生物群调节和减少炎症性细胞因子进行介导.
- 这表明SY在管理与肥胖相关的认知障碍方面具有治疗潜力.
相关概念视频
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01:31Preparation of Carboxylic Acids: Overview
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01:29Preparation of Amides
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