在艾滋病毒患者中同时出现复发性扩散性大B细胞淋巴瘤和肺外结核病:一个病例报告
Toshali Pandey1, Sumant Inamdar2, Susanne Jeffus3
1Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, USA.
Cureus
|March 3, 2025
概括
人类免疫缺陷病毒 (HIV) 增加了扩散大B细胞淋巴瘤 (DLBCL) 和结核病的风险. 这一病例显示了艾滋病毒感染患者同时复发的DLBCL和结核病,强调了诊断挑战.
科学领域:
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 人类免疫缺陷病毒 (HIV) 感染是机会性感染和某些恶性瘤的已知危险因素,包括扩散性大B细胞淋巴瘤 (DLBCL).
- 无论是DLBCL还是结核病 (TB),都可能出现重叠的临床症状,造成严重的诊断和治疗挑战,特别是在感染艾滋病毒的人群中.
研究的目的:
- 报告一个独特的同时复发的DLBCL病例,其中包括脊髓损伤和中腔淋巴结结结核病在一个艾滋病毒感染的个体中.
- 突出艾滋病毒患者多个同时存在的诊断的潜力.
主要方法:
- 一个艾滋病毒感染患者的病例报告.
- 临床表现和诊断工作,包括活检.
- 对同时感染患者的诊断挑战的审查.
主要成果:
- 这位患者同时出现了复发的DLBCL (脊髓) 和结核病 (中腔淋巴结).
- 干扰素玛释放试验 (IGRA) 在这种HIV阳性患者中显示出对结核病检测的低灵敏度.
- 坚持抗逆转录病毒治疗 (ART) 对DLBCL缓解至关重要.
结论:
- 感染艾滋病毒的个体可以同时出现多个严重的诊断.
- 活检的低门对于复杂的艾滋病毒病例的准确诊断至关重要.
- 有效的管理需要解决机会性感染和血液性恶性瘤,而ART坚持是关键.
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