与低剂量提尔泽帕蒂德相关的急性功能性胃出口阻塞
Mina Iskander1, Manish Wadhwa1, Yeongjin Kim1
1Internal Medicine, North Alabama Medical Center, Florence, USA.
Cureus
|March 3, 2025
概括
提尔泽帕提德是一种流行的减肥药,可能会导致严重的胃肠道问题,如胃出口阻塞. 本案例报告强调需要意识到这些潜在的副作用,即使是低剂量.
科学领域:
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 肥胖是一个主要的全球健康问题,需要有效的管理策略.
- 葡萄糖类-1受体激动剂 (GLP-1RA) 越来越多地用于减肥.
- 蒂尔泽帕提德是一种显著的GLP-1RA,显示出显著的疗效.
研究的目的:
- 报告严重的胃肠道副作用的病例,可能与tirezepatide相关.
- 强调在差异诊断中考虑药物诱导效应的重要性.
- 强调医生和患者对提尔泽帕提德不良反应的教育.
主要方法:
- 一个57岁的男性患有2型糖尿病,接受低剂量蒂尔泽帕提德治疗的病例报告.
- 严重的腹痛和吐的临床表现.
- 诊断工作包括食道胃二透镜 (EGD).
主要成果:
- 患者表现出与急性功能性胃出口阻塞一致的症状.
- 在EGD中,没有发现任何解剖学异常.
- 在断药后出现症状缓解,这表明存在因果关系.
结论:
- 蒂尔泽帕提德,即使是低剂量,也可能导致严重的胃肠道不良事件.
- 应该考虑功能性胃输出管阻塞在治疗特泽帕提德的患者出现相关症状.
- 意识和教育对于管理与提尔泽帕提德相关的潜在胃肠道并发症至关重要.
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