抗结核药物诱导的免疫过敏性肝炎:一个案例报告
Mohamed Lakhal1,2, Meriem Rhazari1,2, Sara Gartini1,2
1Department of Respiratory Diseases, Research and Medical Sciences Laboratory, Centre Hospitalier Universitaire Mohammed VI, Oujda, MAR.
Cureus
|March 3, 2025
概括
结核病治疗的副作用,如免疫过敏性肝炎,可能会使恢复复杂化. 这项案例研究表明,药物重新引入和脱敏的成功,允许继续治疗肺结核病.
科学领域:
- 医学 医学 医学 医学 医学
- 药理学 药理学是指药理学的学科.
- 肝病学 肝病学是一种肝病学.
背景情况:
- 抗结核疗法可能会导致不良药物反应,包括免疫过敏反应.
- 免疫过敏反应构成了管理挑战,可能导致治疗中断并影响患者的治疗结果.
研究的目的:
- 在抗结核治疗期间报告免疫过敏性肝炎病例.
- 为了说明一种成功的策略来管理结核病患者的药物诱导肝损伤.
主要方法:
- 一名患有多发肺结核的42岁患者在标准抗结核治疗期间发生肝细胞溶解.
- 免疫过敏性肝炎的诊断通过症状发作的延迟和药物停用后的快速改善而得到证实.
- 在密切监测下进行了逐步的药物重新引入和利芬素脱敏.
主要成果:
- 患者在开始抗结核治疗5天后出现吐和肝酶升高.
- 停止服用抗结核药物导致肝功能测试的快速正常化.
- 乙博醇,皮拉津胺和异化物被顺序地成功地重新引入.
- 利芬素脱敏治疗完成,没有任何不良事件.
结论:
- 免疫过敏性肝炎是抗结核药物的显著不良影响,需要谨慎管理.
- 系统的药物重新引入和脱敏方案可以使必要的抗结核疗法的延续.
- 这一案例突显出一种可行的方法来管理结核病患者的药物诱导肝损伤,确保治疗的坚持和恢复.
相关概念视频
Pulmonary Tuberculosis I
215
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
215
Pulmonary Tuberculosis V
163
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
163
Pulmonary Tuberculosis IV
128
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
128
Allergic Drug Reactions
803
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
803
Pulmonary Tuberculosis III
291
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
291
Pulmonary Tuberculosis II
208
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
208


