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移植后循环胺诱导的心脏毒性:综合性综述

Azin Alizadehasl¹, Bita Shahrami^2,3, Reza Rahbarghazi^4,5

¹Cardio-Oncology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, Iran.

Journal of cardiovascular and thoracic research

|March 3, 2025

概括

环胺可以伤害心脏,特别是在干细胞移植后. 准其有毒代谢物,阿克罗莱因,为管理这种心脏毒性提供了有希望的策略.

科学领域:

心脏病学心脏病学
在瘤学瘤学.
毒理学毒理学毒理学

背景情况:

环胺 (CP) 是一种广泛使用的化疗剂.
CP诱导的心脏毒性是一种严重的不良影响,与其代谢物阿克罗莱因有关.
即使使用低剂量的CP,心脏毒性也可能发生,特别是在血造干细胞移植 (HSCT) 接受者中.

研究的目的:

审查HPT接受者CP治疗的挑战.
讨论CP诱导心脏毒性的机制.
探索针对阿克罗莱因的治疗策略.

主要方法:

对循环胺治疗和心脏毒性研究的文献综述.
对参与CP诱导心肌病的信号通路的分析.
评估阿克罗莱因的作用和潜在的治疗干预措施.

主要成果:

高剂量的CP具有显著的心脏毒性风险.
低剂量CP也在HSCT后的患者中引起心脏毒性问题.
阿克罗莱因的抗血管性作用是CP心脏毒性的关键因素.

结论:

在HSCT接受者中控制CP诱导的心脏毒性仍然具有挑战性.
了解阿克罗莱因的机制对于开发有效的治疗方法至关重要.
准阿克罗莱因的抗血管原效应显示了减轻CP心脏毒性的前景.

关键词:

亚克罗莱因是一种蛋白质.血管新生的产生.心脏有毒性 - 心脏有毒性环酸胺的使用方法造血干细胞移植造血干细胞移植

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