为了实现机器学习的公平性,将结直肠或肺癌患者的多类死亡原因分类为多类
Catherine H Feng1, Fei Deng2, Mary L Disis3
1Harvard University, Cambridge, Massachusetts.
bioRxiv : the preprint server for biology
|March 3, 2025
概括
机器学习模型在将癌症患者的生存率分类到不同年龄,性别和种族群体时显示出偏差. 将模型与社会人口统计数据合并或定制的策略可以提高公平性和整体绩效.
科学领域:
- 在瘤学瘤学.
- 生物统计学 生物统计学
- 人工智能在医学中的应用
背景情况:
- 机器学习 (ML) 模型对于个性化癌症治疗至关重要,但可以从数据和算法中继承偏差.
- 之前的研究发现了ML中的种族偏见,但跨年龄和性别群体的公平性仍未得到充分研究.
研究的目的:
- 在癌症患者生存率分类中,在社会人口统计组 (年龄,性别,种族) 中比较五个ML模型的性能和公平性.
- 为了验证结直肠癌和肺腺癌数据集中的发现.
主要方法:
- 评估了五种ML模型:随机森林,多项逻辑回归,线性支向量分类器,线性差分分析和多层感知.
- 使用了结直肠癌 (n=515) 和肺腺癌 (n=589) 患者数据集的TCGA数据.
- 评估不同年龄,性别和种族小组的模型性能.
主要成果:
- 在这五种ML模型中,在两种癌症类型中,社会人口统计学群体的表现都表现出偏差.
- 令人惊的是,模型在更大的社会人口统计学群体中表现更差.
- 在合并组上测试模型或创建量身定制的模型显示了减少差异的潜力.
结论:
- 癌症存活率分类的ML模型在不同患者群体中本质上并不公平.
- 制定优化ML公平性的策略,例如针对特定群体的模型培训和测试,是必不可少的.
- 这些方法可以在不损害整体预测性能的情况下提高ML权益.
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