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免疫细胞中的连接体歧视:对ER+乳腺癌中免疫功能障碍的信号处理洞察

Adina Matache¹, Joao Rodrigues Lima², Maxim Kuznetsov¹

¹Department of Computational and Quantitative Medicine, Beckman Research Institute of City of Hope, Duarte, CA, 91010 USA.

bioRxiv : the preprint server for biology

|March 3, 2025

概括

乳腺癌患者的免疫细胞信号受损,识别信号的准确性降低,分子噪声增加. 这种功能障碍类似于由JAK1/2抑制剂引起的功能障碍,这表明个性化治疗的潜力.

科学领域:

免疫学免疫学免疫学
系统生物学系统生物学
信号传输信号传输

背景情况:

大约40%的雌激素受体阳性 (ER+) 乳腺癌 (BC) 患者在诊断时表现出免疫信号缺陷.
这些免疫缺陷与ER+乳腺癌患者的整体生存率较差有关.
免疫信号错误的定量表征对于了解患者的预后和治疗反应至关重要.

研究的目的:

开发和应用一种结合通信理论和信号处理的新型模型,以定量评估免疫细胞中的连接体歧视.
与健康对照人群相比,测量ER+乳腺癌患者免疫细胞信号特异性和分子噪声.
评估JAK1/2抑制对免疫细胞连接体歧视的影响.

主要方法:

一个基于通信理论和信号处理的新型模型被开发出来,以估计连接体识别中的错误概率.
使用高维光谱流细胞计测量,测量免疫细胞中的转录因子 (酸化STAT和SMAD).
通过各种细胞因子刺激了19名ER+乳腺癌患者和32名健康对照者的免疫细胞; 额外的分析包括10名用JAK1/2抑制剂治疗的健康捐赠者.

主要成果:

与健康对照组相比,乳腺癌患者表现出显著降低的连接体识别准确性和高分子噪声.
在健康的捐赠者中抑制JAK1/2导致联体错误识别和分子噪声率与乳腺癌患者的水平相当或超过.
这些发现表明ER+乳腺癌患者潜在的免疫细胞功能障碍.

结论:

在ER+乳腺癌患者中,免疫细胞连接体的歧视受损,其特征是精度降低和分子噪声增加.
抑制JAK1/2模仿或加剧了乳腺癌患者观察到的免疫信号缺陷.
评估免疫细胞连接体歧视特异性可能有助于优化在乳腺癌治疗中使用信号激酶抑制剂疗法.

关键词:

CD4+ CD4+ CD4+ CD4+ CD4+ CD4+ CD4+ CD4+ CD4+ CD4+ CD4+ CD4+在ER+乳腺癌.杰克·斯塔特表示细胞通信的细胞通信.免疫信号传递是免疫信号传递.信息理论信息理论相关的歧视和歧视.周围血液周围血液

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