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时机问题:模拟孕期大麻暴露对社会行为和桃体发育中的微质细胞的影响

Aidan L Pham¹, Ashley E Marquardt^1,2, Kristen R Montgomery^1,3

¹Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

bioRxiv : the preprint server for biology

|March 3, 2025

概括

怀孕期间使用大麻会影响胎儿的大脑发育. 暴露于delta-9-tetrahydrocannabinol (THC) 影响微质功能和社会行为,影响因妊娠时间而异.

科学领域:

神经科学是一个神经科学.
发展生物学发展生物学
药理学药理学是指药理学的学科.

背景情况:

怀孕期间大麻的使用量正在增加,许多人认为它是安全的.
主要的精神活性成分德尔塔-9-四大麻素 (THC) 与内分泌大麻素 (eCB) 系统相互作用.
对于THC对胎儿神经发育的影响,特别是通过微质通路的影响,仍然不太清楚.

研究的目的:

研究THC暴露对小质功能和发展中的动物社会行为的影响.
为了确定怀孕期间THC暴露的时间是否会影响发育结果.

主要方法:

动物在产后早期发育 (产后注射) 或子宫内 (母体注射) 暴露于THC.
在青春期评估了微细胞化和社会行为.
分析了THC暴露的性别特异性影响.

主要成果:

产后THC暴露诱导了微质细胞化和青少年社会行为的性别特异性变化.
与产后暴露相比,产前THC暴露导致了细胞和社会行为的反向变化.
这些结果表明基于妊娠暴露时间的不同结果.

结论:

怀孕期间暴露于THC可能会扰乱后代的正常神经发育和行为.
暴露于THC的时间 (产前与产后) 显著影响特定的发育效应.
这些发现强调了考虑妊娠时间的重要性,以了解大麻对胎儿神经发育的影响.

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