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Updated: May 24, 2025

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
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结肠炎的克隆记忆积累并促进瘤生长

Surya Nagaraja, Lety Ojeda-Miron, Ruochi Zhang

    bioRxiv : the preprint server for biology
    |March 3, 2025
    PubMed
    概括

    慢性炎症在结肠干细胞中留下了表观遗传记忆,增加了癌症风险. 这种记忆是由激活蛋白1 (AP-1) 活动驱动的,加速瘤生长,并建议新的治疗点.

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