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Updated: Jun 16, 2026

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
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IFN-α诱导人体β细胞中异质ROS的产生

Leslie E Wagner1, Olha Melnyk2, Abigail Turner2

  • 1Departments of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN.

bioRxiv : the preprint server for biology
|March 3, 2025
PubMed
概括

干扰素α (IFN-α) 在健康的人类β细胞中触发反应性氧物种 (ROS),而不是来自1型糖尿病捐赠者的β细胞. 这表明它可能在抗病毒防御中发挥作用.

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Insulin Secretory Vesicles01:05

Insulin Secretory Vesicles

Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...